TGFβ-IN-2 - CAS 2387678-02-4

TGFβ-IN-2 (Compound 9d) effectively inhibits TGF-β-induced accumulation of total collagen in NRK-49F cells, with an IC50 value of 4.31 μM. It also suppresses the TGF-β-induced in vitro expression of COL1A1, α-SMA, and p-Smad3. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].

Others, TGF-beta/Smad

Stem Cells, Others

2387678-02-4

C22H22N2O4

378.42

O(C=1C=2C(OC(=O)C1)=CC=CC2)C3=CC=C(NC(CN4CCCCC4)=O)C=C3

-20°C

Ice Packs

Small Compound