TGFβRII-IN-3 - CAS 2351149-20-5

TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) with an IC50 of 4.1 μM. It inhibits TGFβ signaling by promoting protein degradation of TGFβ RII. Additionally, TGFβRI-IN-7 can block the transition from endothelial to mesenchymal states and inhibit cell migration, making it useful for cancer research.

TGF-beta/Smad

Stem Cells

2351124

C27H27F3N2O2

468.51

O=C(C=1C=2C(=O)CC(C)(C)CC2NC1C)N(C)CC3=CC=CC(=C3)C4=CC=C(C=C4)C(F)(F)F

-20°C

Ice Packs

Small Compound