TH-Z827 - CAS 2847881-81-4

TH-Z827 is a mutant-selective inhibitor targeting KRAS (G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS (WT) or KRAS (G12C) . Additionally, it disrupts the KRAS (G12D) -CRAF interaction with an IC50 of 42 μM [1].

Ras

MAPK, GPCR/G Protein

2847796

C30H38N6O

498.66

O(C[C@H]1N(C)CCC1)C2=NC(=C3C(CN(CC3)C=4C5=C(C=CC4)C=CC=C5C)=N2)N6C7CCC6CNC7

-20°C

Ice Packs

Small Compound