TH287 hydrochloride - CAS 1638211-05-8

TH287 is a selective MTH1 inhibitor (IC50 : 0.8 nM) . It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

DNA/RNA Synthesis, MTH1

DNA Damage/DNA Repair, Cell Cycle/Checkpoint

1638211-05-8

>99.99%

C11H11Cl3N4

305.59

NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl

-20°C

Ice Packs

Small Compound