TH5427 hydrochloride - CAS 2253744-57-7

TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.

Others, DNA/RNA Synthesis

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others

2253680

C20H21Cl3N8O3

527.79

Cl.Cn1c2nc(N3CCNCC3)n(Cc3nnc(o3)-c3ccc(Cl)c(Cl)c3)c2c(=O)n(C)c1=O

-20°C

Ice Packs

Small Compound