TH9619 - CAS 2379556-22-4

TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM) . It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2.

Antifolate, Cell Cycle Arrest, DHFR

Metabolism, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

2379556-22-4

0.9807

C17H18FN7O7

451.37

N(C(CC1=C(N)NC(N)=NC1=O)=O)C=2C=C(F)C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=NC2

-20°C

Ice Packs

Small Compound