Thalidomide 4'-ether-PEG2-azide - CAS 2758431-90-0

Thalidomide 4'-ether-PEG2-azide is a modified form of the cereblon (CRBN) inhibitor Thalidomide, created through click chemistry. Featuring an azide group, this compound can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It serves as a ligand for E3 ubiquitin ligase and as a linker conjugate (E3LigaseLigand-Linker Conjugates) for use in PROTACs.

E3 Ligase Ligand-Linker Conjugate

PROTAC

2758341

C19H21N5O7

431.4

[N-]=[N+]=NCCOCCOCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

-20°C

Ice Packs

PROTAC