Thalidomide-4-NH-PEG1-COOH TFA - CAS 2140807-20-9

Thalidomide-4-NH-PEG1-COOH TFA is a conjugate of an E3 ligase ligand and linker, composed of Thalidomide and NH-PEG3-NH-Boc. It serves as a Cereblon? ligand, facilitating the recruitment of CRBN? protein. This compound is a crucial intermediate in the synthesis of PROTAC molecules designed based on CRBN.

E3 Ligase Ligand-Linker Conjugate

PROTAC

2140778

C20H20F3N3O9

503.38

O=C(O)CCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3.O=C(O)C(F)(F)F

-20°C

Ice Packs

PROTAC