Thalidomide-O-C3-azide - CAS 2758432-00-5

Thalidomide-O-C3-azide is a chemically modified version of the cereblon (CRBN) inhibitor Thalidomide through click chemistry. It features an azido group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Thalidomide-O-C3-azide serves as a ligand for E3 ubiquitin ligase and a component in E3 Ligase Ligand-Linker Conjugates, facilitating the synthesis of PROTACs.

E3 Ligase Ligand-Linker Conjugate

PROTAC

2758432-00-5

C16H15N5O5

357.32

[N-]=[N+]=NCCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

-20°C

Ice Packs

PROTAC