Thalidomide-O-C5-azide - CAS 2411098-96-7

Thalidomide-O-C5-azide is a modified form of the cereblon (CRBN) inhibitor thalidomide, created through click chemistry. It contains an azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkynyl-containing molecules. Thalidomide-O-C5-azide serves as a ligand and linker conjugate for E3 ubiquitin ligase, facilitating the synthesis of PROTACs.

E3 Ligase Ligand-Linker Conjugate

PROTAC

2410995

C18H19N5O5

385.37

[N-]=[N+]=NCCCCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

-20°C

Ice Packs

PROTAC