Thiocoraline - CAS 173046-02-1

Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus, B. subtilis, andM. luteus (MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli, K. pneumoniae, orP. aeruginosa (MICs = >100 μg/ml for all) .1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA synthesisin vitro (IC50s = 0.008 and 0.4 μg/ml, respectively) . It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 μg/ml, respectively) .

Others, Antibacterial

Others, Microbiology/Virology

173046-02-1

C48H56N10O12S6

1157.39

CSCC1N(C)C(=O)C2CSSCC(N(C)C(=O)CNC(=O)C(CSC1=O)NC(=O)c1nc3ccccc3cc1O)C(=O)N(C)C(CSC)C(=O)SCC(NC(=O)c1nc3ccccc3cc1O)C(=O)NCC(=O)N2C

-20°C

Ice Packs

Small Compound