THR-β agonist 6 - CAS 2791290-58-7

THR-β Agonist 6, a selective and orally active compound targeting the thyroid hormone receptor β (THR-β), demonstrates specificity with EC50 values of 0.03 μM for THR-β and 0.22 μM for THR-α. This compound boasts a remarkable liver-to-serum ratio of 93:1 in mouse models, underscoring its efficacy and potential for research in nonalcoholic steatohepatitis (NASH) [1].

Others, Thyroid hormone receptor (THR)

Others, Endocrinology/Hormones

2791225

C20H14Cl2N6O3

457.27

ClC1=C(N2C3=C(C=C2)N(C(C)C)C(=O)C=C3)C(Cl)=CC(=C1)N4N=C(C#N)C(=O)NC4=O

-20°C

Ice Packs

Small Compound