THR-β agonist 9 - CAS 2920045-74-3

THR-β agonist 9 is a potent and selective THR-β activator, which shows sensitivity to His435 mutations with an EC50 of 3.2 nM. It demonstrates moderate selectivity, approximately 10-fold, and effectively activates various His435 mutants (H435A, H435Y, and H435R), with EC50 values ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 presents potential for research into conditions such as dyslipidemia, metabolic syndrome-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH) .

Acetyl-CoA Carboxylase, AMPK, Mitochondrial Metabolism, Thyroid hormone receptor (THR)

Endocrinology/Hormones, PI3K/Akt/mTOR signaling, Metabolism, Chromatin/Epigenetic

2919968

C23H18N2O6

418.4

O=C(O)CNC(=O)C1=NC(OC)=C2C=C(OC=3C=CC=4C=CC=CC4C3)C=CC2=C1O

-20°C

Ice Packs

Small Compound