TIC10g - CAS 754998-88-4

TIC10g is a dual inhibitor of Toll-like receptors 7 and 9 (TLR7 and TLR9), effectively suppressing the release of TNF-α mediated by TLR7 and TLR9 in mouse macrophages (with IC50 values of 14.5 μM and 6.5 μM, respectively) and in human B lymphocytes (with IC50 values of 7.69 μM and 11.5 μM, respectively) . TIC10g inhibits the activation of NF-κB and MAPK, exhibiting anti-inflammatory activity useful in treating conditions such as systemic lupus erythematosus and rheumatoid arthritis.

NF-κB, p38 MAPK, TLR

NF-κB, Immunology/Inflammation, MAPK

754998-88-4

C20H21N3O4

367.4

N=1C=C(C=2C=CC=3OCOC3C2)N(C1NCC4=CC=C(OC)C=C4OC)C

-20°C

Ice Packs

Small Compound