Ticolubant - CAS 154413-61-3

Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inflammatory activity in a mouse model of skin inflammation.

Leukotriene Receptor, Calcium Channel, LTR

Membrane transporter/Ion channel, GPCR/G Protein, Immunology/Inflammation, Metabolism

154349

0.9959

C23H19Cl2NO3S

460.37

C(=C/C(O)=O)\C1=C(OCCC2=CC=CC=C2)C=CC(CSC3=C(Cl)C=CC=C3Cl)=N1

-20°C

Ice Packs

Small Compound