Timegadine hydrochloride - CAS 71080-06-3

Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine. It is an orally active inhibitor of COX and lipo-oxygenase, effectively suppressing COX in rabbit platelets and rat brain with IC50 values of 5 nM and 20 μM, respectively, and inhibiting lipo-oxygenase in horse and rabbit platelets with an IC50 of 100 μM. Timegadine hydrochloride also exhibits anti-arthritis activity.

COX

Immunology/Inflammation, Neuroscience

71080-06-3

C20H24ClN5S

401.96

Cl.N=1C=CSC1NC(=NC2=CC(=NC=3C=CC=CC32)C)NC4CCCCC4

-20°C

Ice Packs

Small Compound