Tinengotinib - CAS 2230490-29-4

Tinengotinib is a multikinase inhibitor targeting a series of kinases involved in cancer cell proliferation, angiogenesis, and regulation of immune response, including Aurora kinase A/B, Janus kinase (JAK1/2), fibroblast growth factor receptor (FGFR1/2/3), vascular endothelial growth factor receptors (VEGFRs), and other tyrosine kinases. Tinengotinib has shown good tolerability and preliminary efficacy in clinical trials in a variety of advanced solid tumors.

FGFR, VEGFR, Aurora Kinase, JAK, Tyrosine Kinases

JAK/STAT signaling, Stem Cells, Angiogenesis, Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, Chromatin/Epigenetic

2230457

0.9905

C20H19ClN6O

394.86

ClC=1C=CC=CC1C2=NC=3C(=NNC3C)NC=4C=C(N=CC24)N5CCOCC5

-20°C

Ice Packs

Small Compound