TIP48/49-IN-1 - CAS 1807337-58-1

TIP48/49-IN-1 (Compound B) is an orally active, specific RUVBL1/2 ATPase inhibitor, with an IC50 of 59 nM for purified RUVBL1/2. It disrupts the DNA replication process, causing S phase arrest, induces apoptosis, inhibits tumor growth, and enhances the radiosensitivity of non-small cell lung cancer cells (NSCLC) .

Proton pump

Membrane transporter/Ion channel

1807278

C28H30ClN5O4

536.022

O(CC)C1=C(C=2OC(=NN2)[C@@H]3C[C@H](C(NC=4C(=O)N(N(C)C4C)C5=CC=CC=C5)=O)CCC3)C=C(Cl)C=C1

-20°C

Ice Packs

Small Compound