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Tirabrutinib - CAS 1351636-18-4

Tirabrutinib - CAS 1351636-18-4

MF-0018487-01

$31.68 USD
$31.68 USD
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Product Details

  • Bioactivity

    Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB) ), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of autoimmune diseases and hematological malignancies.

  • Target

    BTK, Apoptosis

  • Related Pathways

    Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis

  • CAS Number

    1351614

  • Purity

    0.9975

  • Molecular Formula

    C25H22N6O3

  • Molecular Weight

    454.48

  • SMILES

    CC#CC(=O)N1CC[C@H](C1)n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound