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Molfinity

TL12-186 - CAS 2250025-88-6

TL12-186 - CAS 2250025-88-6

MF-0093937-01

$59.34 USD
$59.34 USD
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Product Details

  • Bioactivity

    TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.

  • Target

    PROTACs, CDK

  • Related Pathways

    PROTAC, Cell Cycle/Checkpoint

  • CAS Number

    2249931

  • Purity

    0.982

  • Molecular Formula

    C44H51ClN10O9S

  • Molecular Weight

    931.46

  • SMILES

    O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCC(=O)NCCOCCOCCN4CCN(C5=CC=C(C=C5)NC6=NC=C(Cl)C(=N6)NC=7C=CC=CC7S(=O)(=O)C(C)C)CC4)C3C2=O)CC1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    PROTAC