TLR7/8 agonist 13 - CAS 1402802-45-2

TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (with a lowest effective concentration (LEC) [hTLR7] of 1.6 μM) and TLR8 (LEC [hTLR8] of 1.6 μM) . It acts on human peripheral blood mononuclear cells (hPBMC) with agonistic activity (LEC [hPBMC] = 0.5 μM) . In mice and cynomolgus monkeys, TLR7/8 agonist 13 induces endogenous IFNα, activates myeloid dendritic cells and monocytes, promoting their differentiation towards a TH1 phenotype. In chronic AAV-HBV mouse models, it reduces viral load and HBV surface antigen levels. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, facilitating the response of HBV antigen-specific CD8 T cells. This compound is useful for hepatitis B virus research.

Interleukin, TLR, HBV, IFNAR

Microbiology/Virology, Immunology/Inflammation

1402755

C12H22N4O2

254.33

N([C@@H](CCCC)CCO)C=1C(OC)=CN=C(N)N1

-20°C

Ice Packs

Small Compound