TLR7/8 agonist 8 - CAS 2649170-16-9

TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8) . This compound enhances the efficacy of PD-1/PD-L1 inhibitors in antitumor activity [1].

Others, TLR

Immunology/Inflammation, Others

2649145

C24H30N6O

418.53

C(N1CC2(C1)COC2)C3=CC=C(CC4=NC5=C(C=C4)N=C(N)N=C5NCCCC)C=C3

-20°C

Ice Packs

Small Compound