TLR8 agonist 8 - CAS 3034750-58-5

TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.

TLR

Immunology/Inflammation

3034750-58-5

C53H63N11O10

1014.14

C(NC=1C=C2C(=NC1)CCN(C(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(=O)C=CC4=O)=O)=O)=O)=O)=O)C2)(=O)C5(CC5)C=6C=C7C(=CC6)C=C(C(N(CCC)CCO)=O)CC(N)=N7

-20°C

Ice Packs

Small Compound