TM2 TEAD inhibitor - CAS 1008768-41-9

TM2 TEAD inhibitor is an effective and reversible inhibitor of TEA domain transcription factors, exhibiting IC50 values of 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively. TM2 TEAD inhibitor blocks TEAD-YAP binding and suppresses its transcriptional activity, exhibiting significant antiproliferative effects in YAP-dependent cancer cells. It demonstrates potent efficacy both as a monotherapy and in combination with MEK inhibitors. Furthermore, TM2 TEAD inhibitor strongly inhibits YAP-dependent liver organoid growth in vitro, supporting its potential application as an anticancer therapeutic strategy.

YAP

Stem Cells

1008768-41-9

0.9991

C26H33N3O3

435.57

O=C(NC=1C=CC=CC1)N2CCN(C(=O)C=3C=CC=C(OCCC4CCCCC4)C3)CC2

-20°C

Ice Packs

Small Compound