TM471-1 - CAS 2649008-95-5

TM471-1 is an orally active, covalent Bruton’s tyrosine kinase (BTK) inhibitor displaying an IC0 value of 1.3 nM for BTKWT, > 40000 nM for BTKC481S, 7.9 nM for TEC, and 12.4 nM for TXK. It inhibits cell growth both in vitro and in vivo, arrests the cell cycle at the G0/G1 phase, and induces apoptosis.

BTK, Apoptosis

Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors

2648908

C27H29N5O3

471.55

C(N)(=O)C=1N2C([C@@H](CCN2)C3CCN(C(C=C)=O)CC3)=NC1C4=CC=C(OC5=CC=CC=C5)C=C4

-20°C

Ice Packs

Small Compound