TM5441 - CAS 1190221-43-2

TM5441 is an orally bioavailable fibrinogen activator inhibitor-1 inhibitor that inhibits several cancer cell lines with IC50 values ranging from 13.9 to 51.1 μM.It induces intrinsic cell death in several human cancer cells and attenuates Nω-nitro-1-arginine methyl ester-induced cardiac hypertension and vascular senescence.

PAI-1, Apoptosis

Metabolism, Apoptosis

1190176

0.9909

C21H17ClN2O6

428.82

OC(=O)c1cc(Cl)ccc1NC(=O)COCC(=O)Nc1cccc(c1)-c1ccoc1

-20°C

Ice Packs

Small Compound