TNF-α-IN-18 - CAS 1272322-42-5

TNF-α-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-α) that operates with a IC50 of 1.8μM. TNF-α-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), thereby suppressing the downstream TNF signaling pathway; TNF-α-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 μM. TNF-α-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models.

NF-κB, TNF

NF-κB, Apoptosis

1272322-42-5

0.9977

C16H7ClF2O4

336.67

O=C(O)C=1C(=O)C2=CC=C(Cl)C=C2OC1C=3C=C(F)C=CC3F

-20°C

Ice Packs

Small Compound