TNG-462 - CAS 2760483-96-1

TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP) -deficient and/or methylthioadenosine (MTA) -accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies) .

Histone Methyltransferase

Chromatin/Epigenetic

2760386

0.987

C28H36N6O2S

520.69

C(C(NC=1C=C(CC)C(N)=NC1)=O)(=O)N2[C@H](CC[C@H](C)C2)C=3C=C4C(=CC3)SC(=N4)C5CCN(C)CC5

-20°C

Ice Packs

Small Compound