TNI-97 - CAS 2790425-52-2

TNI-97 is a selective, orally active HDAC6 inhibitor with an IC50 value of 0.2 nM. It significantly suppresses the growth and colony-forming abilities of the triple-negative breast cancer (TNBC) cell line MDA-MB-453. In these cells, TNI-97 induces widespread cell death, including apoptosis, necroptosis, and pyroptosis. Additionally, TNI-97 demonstrates antitumor activity in mouse models bearing MDA-MB-453 xenograft tumors or syngeneic mouse-derived TNBC cell allograft tumors. TNI-97 is useful for researching triple-negative breast cancer.

Apoptosis, Necroptosis, Pyroptosis, HDAC

Immunology/Inflammation, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

2790371

C19H15F3N6O2

416.36

O=C(NO)C1=CC=C(C=C1)CN2N=C(C=C2C(F)(F)F)C3=CC=C4C(N=NN4C)=C3

-20°C

Ice Packs

Small Compound