TNIK-IN-3 - CAS 2754265-25-1

TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK) . It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 μM), Flt1 (IC50 = 0.191 μM), and DRAK1 (IC50 = 0.411 μM) . This compound holds potential for carrying out research on colorectal cancer (CRC) [1].

DAPK, Wnt/beta-catenin

Cytoskeletal Signaling, Stem Cells, Apoptosis

2754239

0.9956

C23H18FN3O2

387.41

Fc1ccc(CN2CCOc3cc(ccc3C2=O)-c2cnc3[nH]ccc3c2)cc1

-20°C

Ice Packs

Small Compound