TNO211 - CAS 193475-71-7

TNO211 is a bioactive peptide that functions as a highly soluble fluorogenic substrate for select Matrix Metalloproteinases (MMPs) —specifically MMP-2, 8, 12, 13, and 14. Incorporating a cleavable Gly-Leu bond and an EDANS/DABCYL fluorophore/quencher pair, TNO211 enables sensitive detection of MMP activity through fluorescence assays, with an absorption/emission profile at 340/490 nm. It is particularly effective in analyzing MMPs in culture media from endothelial cells as well as untreated synovial fluid from patients, highlighting its utility in investigations of MMP-associated cellular behaviors, including proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.

MMP

Proteases/Proteasome

193397

C63H88N16O14S

1325.54

S(=O)(=O)(O)C=1C2=C(C(NCCNC(CC[C@H](NC([C@@H](NC(CNC([C@@H](NC(=O)[C@H]3N(C(CCCNC(=O)C4=CC=C(N=NC5=CC=C(N(C)C)C=C5)C=C4)=O)CCC3)CCC(N)=O)=O)=O)CC(C)C)=O)C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)C)=O)=O)=CC=C2)C=CC1

-20°C

Ice Packs

Peptide