Tofacitinib maleate - CAS 2052885-67-1

Tofacitinib maleate, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib maleate modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2) . Tofacitinib maleate inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.

Others

Others

2052817

C16H20N6O.xC4H4O4

428.449

C(=C\C(O)=O)\C(O)=O.N(C)(C1=C2C(NC=C2)=NC=N1)[C@H]3CN(C(CC#N)=O)CC[C@H]3C

-20°C

Ice Packs

Small Compound