Tolafentrine - CAS 139308-65-9

Tolafentrine is a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor that has demonstrated significant acute and chronic effects in a rat model of pulmonary hypertension induced by monocrotaline. Studies indicate that prolonged administration notably alleviates hemodynamic and gas exchange abnormalities caused by monocrotaline, reduces right ventricular hypertrophy, and normalizes changes in pulmonary vascular remodeling.

PDE

Metabolism

139308-65-9

C28H31N3O4S

505.63

O(C)C=1C=C2C([C@]3([C@@](N=C2C4=CC=C(NS(=O)(=O)C5=CC=C(C)C=C5)C=C4)(CCN(C)C3)[H])[H])=CC1OC

-20°C

Ice Packs

Small Compound