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Tolebrutinib - CAS 1971920-73-6

Tolebrutinib - CAS 1971920-73-6

MF-0094208-01

$36.91 USD
$36.91 USD
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Product Details

  • Bioactivity

    Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor (IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively) . It exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS) .

  • Target

    BTK

  • Related Pathways

    Angiogenesis, Tyrosine Kinase/Adaptors

  • CAS Number

    1971841

  • Purity

    0.992

  • Molecular Formula

    C26H25N5O3

  • Molecular Weight

    455.51

  • SMILES

    Nc1nccc2n([C@@H]3CCCN(C3)C(=O)C=C)c(=O)n(-c3ccc(Oc4ccccc4)cc3)c12

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound