Tomivosertib HCl - CAS 1849590-02-8

Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory proteins, including eukaryotic translation initiation factor 4E (eIF4E), that regulate the translation of messenger RNAs (mRNAs) involved in tumor cell proliferation, angiogenesis, survival and immune signaling.

Others, MNK, PD-1/PD-L1

Apoptosis, Cell Cycle/Checkpoint, Immunology/Inflammation, Others, MAPK

1849590-02-8

C17H21ClN6O2

376.845

Cl.Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1

-20°C

Ice Packs

Small Compound