TOP1288 - CAS 1630202-02-6

TOP1288 is a narrow-spectrum kinase inhibitor targeting P38α, Src, and Syk kinases, with IC 50 values of 116nM, 24nM, and 659nM, respectively. It effectively inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts [1].

Src, Syk, p38 MAPK

Tyrosine Kinase/Adaptors, MAPK, Angiogenesis

1630202-02-6

C43H49N7O9S

839.96

O(C=1C2=C(C(NC(NC3=C(OC)C(NS(C)(=O)=O)=CC(C(C)(C)C)=C3)=O)=CC1)C=CC=C2)C4=NC(NC5=CC(C(NCCOCCOCCOC)=O)=CC(C#C)=C5)=NC=C4

-20°C

Ice Packs

Small Compound