Topobexin - CAS 3076446-44-8

Topobexin (Topobexin 9) is a highly selective TOP2B inhibitor. It selectively inhibits TOP2B in vitro and stabilizes TOP2B on DNA. Topobexin offers significant protection to cardiomyocytes against DAU-induced damage. In rabbit models, Topobexin prevents anthracycline-induced cardiotoxicity and the decrease in left ventricular contractile function caused by DAU.

Topoisomerase

DNA Damage/DNA Repair

3076394

C29H35N3O4

489.61

O=C1OC2=C(C=CC(OCCN3CCN(C)CC3)=C2C(=O)N4C=5C=CC=CC5CCC4)C(=C1)CCC

-20°C

Ice Packs

Small Compound