TOPOI/PARP-1-IN-1 - CAS 2948352-16-5

Compound B6, also known as TOPOI/PARP-1-IN-1, is a dual inhibitor targeting TOPOI and PARP, exhibiting low cytotoxicity and oral activity with a PARP1 IC 50 of 0.09 μM. This compound effectively inhibits cancer cell proliferation and migration, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. In murine models, TOPOI/PARP-1-IN-1 demonstrated a tumor growth inhibition rate (TGI) of 75.4% [1].

Topoisomerase, PARP, Apoptosis

Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

2948352-16-5

C36H38Br2N4O2

718.52

C(CCC=1NC=2C(N1)=CC(Br)=C(Br)C2)[C@@H]3[C@@]4([C@@]5([C@](CN3C(OCC6C=7C(C=8C6=CC=CC8)=CC=CC7)=O)(CCCN5CCC4)[H])[H])[H]

-20°C

Ice Packs

Small Compound