Topoisomerase I inhibitor 17 - CAS 2413582-45-1

TopoisomeraseI inhibitor 17 (Compound 7h) is an inhibitor of TopoisomeraseI (Top1) . It reduces DDX5 and reverses the locking effect of DDX5 on Top1 activity. This compound induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. It triggers apoptosis by decreasing anti-apoptotic proteins XIAP, Bcl-2, and Survivin, while increasing pro-apoptotic proteins Bax and γH2AX. Moreover, TopoisomeraseI inhibitor 17 halts progression at the G2/M checkpoint, leading to cell cycle arrest. It significantly impairs colorectal cancer cell colony formation and migration, and effectively reduces tumor size in human PDX tumor mouse models.

Topoisomerase, IAP, DNA/RNA Synthesis, Survivin, Reactive Oxygen Species, Bcl-2 Family, Apoptosis

NF-κB, Metabolism, Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Immunology/Inflammation

2413536

C28H21FN2O7

516.47

O(C)C=1C=C(C2=C3C(C=4N(C3)C(=O)C5=C(C4)[C@](CC)(O)C(=O)OC5)=NC=6C2=CC7=C(C6)OCO7)C=CC1F

-20°C

Ice Packs

Small Compound