Topoisomerase I inhibitor 5 - CAS 2513461-95-3

Topoisomerase I inhibitor 5 is an efficient topoisomerase I inhibitor with an IC50 value, effectively disrupting DNA and inhibiting topoisomerase I activity. It induces apoptosis in MCF-7 cells and arrests the cell cycle at the G1 phase, displaying potency in reversing P-gp-mediated resistance to Adriamycin [1].

Others, DNA/RNA Synthesis, Apoptosis, Topoisomerase

Others, DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint

2513363

C24H24N2O2

372.46

O(CCN1C(C)CCCC1)C=2C=3C4=C(C=5C(C(=O)C4=CC2)=CC=CC5)N=CC3

-20°C

Ice Packs

Small Compound