Topoisomerase II inhibitor 3 - CAS 99140-25-7

Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative acting as a Type II DNA topoisomerase (topo II) inhibitor. It specifically targets topo IIα/β subtypes, with IC50 values of 0.17 μM for topo IIα and 0.23 μM for topo IIβ, causing significant DNA damage and inducing apoptosis by triggering the loss of mitochondrial membrane potential [1].

Apoptosis, Others, Topoisomerase

Others, DNA Damage/DNA Repair, Apoptosis

99108

C18H20N4O4

356.38

N(=O)(=O)C1=C2C(=C(NCCCN(C)C)C=C1)C(=O)C=3C(N2)=CC=C(O)C3

-20°C

Ice Packs

Small Compound