Topoisomerase IV inhibitor 1 - CAS 2883403-42-5

Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for DNA gyrase. It demonstrates antibacterial efficacy, with minimum inhibitory concentrations (MICs) of 0.972 μM against Staphylococcus aureus Newman and 0.608 μM against Escherichia coli ATCC8739 [1].

Antibacterial, Topoisomerase

Microbiology/Virology, DNA Damage/DNA Repair

2883356

C34H32FN7O6S

685.72

C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCN(CC4)CCC(=O)NC5=CC=C(C=C5)S(=O)(=O)NC6=NC7=CC=CC=C7N=C6)F)C(=O)O

-20°C

Ice Packs

Small Compound