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Molfinity

Topovale - CAS 500214-53-9

Topovale - CAS 500214-53-9

MF-0036121-01

$96.50 USD
$57.20 USD $96.50 USD
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Product Details

  • Bioactivity

    Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1) -deficient P388/CPT45 cells as compared with P388 cells.

  • Target

    Topoisomerase

  • Related Pathways

    DNA Damage/DNA Repair

  • CAS Number

    500214-53-9

  • Purity

    0.9994

  • Molecular Formula

    C23H23N3O5

  • Molecular Weight

    421.45

  • SMILES

    C(CN(C)C)N1C2=C(C=3C(C1=O)=CC(OC)=C(OC)C3)C=NC=4C2=CC5=C(C4)OCO5

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound