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Tos-PEG4-t-butyl ester - CAS 217817-01-1

Tos-PEG4-t-butyl ester - CAS 217817-01-1

MF-0034239-01

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Product Details

  • Bioactivity

    Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition, crucial in synthesizing various PROTACs, including BI-3663, a selective PTK2/FAK PROTAC. Using cereblon ligands, it targets E3 ligases to degrade PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].

  • Target

    Others, PROTAC Linker

  • Related Pathways

    PROTAC, Others

  • CAS Number

    217817-01-1

  • Molecular Formula

    C20H32O8S

  • Molecular Weight

    432.53

  • SMILES

    S(OCCOCCOCCOCCC(OC(C)(C)C)=O)(=O)(=O)C1=CC=C(C)C=C1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    PROTAC