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Molfinity

TP0427736 hydrochloride - CAS 2459963-17-6

TP0427736 hydrochloride - CAS 2459963-17-6

MF-0044216-01

$36.16 USD
$36.16 USD
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Product Details

  • Bioactivity

    TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-β-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles.

  • Target

    ALK, TGF-beta/Smad

  • Related Pathways

    Angiogenesis, Tyrosine Kinase/Adaptors, Stem Cells

  • CAS Number

    2459940

  • Purity

    0.9899

  • Molecular Formula

    C14H11ClN4S2

  • Molecular Weight

    334.85

  • SMILES

    Cl.N1=CSC=2C=C(C=CC12)C=3NC=NC3C4=NC(=CS4)C

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound