TPB15 - CAS 2170347-69-8

TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein and mRNA expression. TPB15 has good anti-tumour effects and low toxicity.

Apoptosis, Others, Hedgehog/Smoothened, Smo

GPCR/G Protein, Apoptosis, Stem Cells, Others

2170270

C18H9Cl4N5O

453.11

ClC=1C(C=2N3C(=NN2)C(Cl)=CC=C3)=CC(NC(=O)C4=C(Cl)N=C(Cl)C=C4)=CC1

-20°C

Ice Packs

Small Compound