TPBM - CAS 6466-43-9

TPBM is a potent inhibitor of estrogen receptor α (ERα) . The IC 50 value of TPBM for 17β-estradiol (E2) -ERα is 9 μM. TPBM is not toxic to cells and reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells with an IC 50 value of 5 μM. TPBM does not affect estrogen-independent cell growth [1].

Estrogen Receptor/ERR, Others

Others, Endocrinology/Hormones

6414

C15H16N4O2S

316.38

O=C1C2=C(N=C(CSCC3=CC=CC=C3)N2)N(C)C(=O)N1C

-20°C

Ice Packs

Small Compound