TpD - CAS 1273551-45-3

TpD is a chimeric T-helper epitope that features a specific site for cleavage by caspases. Immunization with TpD induces a strong antibody response and enhances long-term CD4 immune reactions in both animals and humans. It effectively binds to various human MHCII types, primarily HLA-DRB1, and also interacts with other HLA alleles, including DRB3, DRB4, DRB5, DP, and DQ. TpD can be utilized to amplify the immune response in peptide vaccines.

MHC

Immunology/Inflammation

1273551-45-3

C158H264N38O42S3

3464.21

C([C@@H](NC(CNC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CC(C)C)=O)CCSC)=O)CCC(N)=O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)C)=O)CC(N)=O)=O)CO)=O)CCCCN)=O)=O)[C@H](CC)C)=O)=O)[C@H](CC)C)(=O)N3[C@H](C(N[C@H](C(NCC(N[C@H](C(=O)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)C)=O)C(C)C)=O)CCSC)=O)CC(C)C)=O)CO)=O)CO)=O)CC(C)C)=O)C)=O)[C@H](CC)C)=O)CO)=O)CCC(N)=O)=O)CCC4)CC(C)C)=O)=O)CCSC)=O)CCC3

-20°C

Ice Packs

Peptide