TQ-3959 - CAS 2926610-43-5

TQ-3959 is an orally active BTKPROTAC degrader, with a DC50 of 14.6 nM. It exhibits antiproliferative activity against both wild-type BTK and BTK C481S mutant cell lines. TQ-3959 demonstrates tumor growth inhibition in female NOD-SCID mice with TMD-8 xenografts. This compound is applicable in the study of B-cell malignancies, such as lymphoma.

BTK, PROTACs

Tyrosine Kinase/Adaptors, PROTAC, Angiogenesis

2926562

C40H47N11O5

761.87

O=C1C(C=2C=3C(=CC(=CC3)N4CC(C4)N5CCC(CC5)C6=CC=C(NC7=NC(=CN=C7C(N)=O)N8C[C@@H](CCC8)N9C(=O)N(C)CC9)C=C6)ON2)CCC(=O)N1

-20°C

Ice Packs

PROTAC