TQ05310 - CAS 2071196-10-4

TQ05310 is an orally active inhibitor of mutant IDH2, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutations. This compound suppresses the production of 2-hydroxyglutarate (2-HG) by inhibiting the enzymatic activity of mutant IDH2, and induces differentiation in cells expressing IDH2-R140Q and IDH2-R172K. TQ05310 is utilized in research on acute myeloid leukemia.

Isocitrate Dehydrogenase (IDH)

Metabolism

2071196-10-4

C19H17F6N7O

473.38

FC(F)(F)C1=NC(=CC=C1)C2=NC(=NOC(C)(C)C)N=C(N2)NC=3C=CN=C(C3)C(F)(F)F

-20°C

Ice Packs

Small Compound